Tracing the roots of ion channels

LY Jan, YN Jan - Cell, 1992 - cell.com
LY Jan, YN Jan
Cell, 1992cell.com
We have generated mice carrying a mutation of the gene encoding the low affinity NGF
receptor p75 NGFR by targeted mutation in embryonic stem cells. Mice homozygous for the
mutation were viable and fertile. Immunohistochemical analyses of the footpad skin of
mutant mice revealed markedly decreased sensory innervation by calcitonin gene-related
peptide-and substance P-immunoreactive fibers. The defective innervation was correlated
with loss of heat sensitivity and associated with the development of ulcers in the distal …
We have generated mice carrying a mutation of the gene encoding the low affinity NGF receptor p75 NGFR by targeted mutation in embryonic stem cells. Mice homozygous for the mutation were viable and fertile. Immunohistochemical analyses of the footpad skin of mutant mice revealed markedly decreased sensory innervation by calcitonin gene-related peptide-and substance P-immunoreactive fibers. The defective innervation was correlated with loss of heat sensitivity and associated with the development of ulcers in the distal extremities.
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