A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes
CJ Boushey, SAA Beresford, GS Omenn, AG Motulsky - Jama, 1995 - jamanetwork.com
Objective.—To determine the risk of elevated total homocysteine (tHcy) levels for
arteriosclerotic vascular disease, estimate the reduction of tHcy by folic acid, and calculate
the potential reduction of coronary artery disease (CAD) mortality by increasing folic acid
intake. Data Sources.—MEDLINE search for meta-analysis of 27 studies relating
homocysteine to arteriosclerotic vascular disease and 11 studies of folic acid effects on tHcy
levels. Study Selection and Data Extraction.—Studies dealing with CAD, cerebrovascular …
arteriosclerotic vascular disease, estimate the reduction of tHcy by folic acid, and calculate
the potential reduction of coronary artery disease (CAD) mortality by increasing folic acid
intake. Data Sources.—MEDLINE search for meta-analysis of 27 studies relating
homocysteine to arteriosclerotic vascular disease and 11 studies of folic acid effects on tHcy
levels. Study Selection and Data Extraction.—Studies dealing with CAD, cerebrovascular …