[HTML][HTML] Hypoxia and nitric oxide induce a rapid, reversible cell cycle arrest of the Drosophila syncytial divisions
PJ DiGregorio, JA Ubersax, PH O'Farrell - Journal of Biological Chemistry, 2001 - ASBMB
Cells can respond to reductions in oxygen (hypoxia) by metabolic adaptations, quiescence
or cell death (1). The nuclear division cycles of syncytial stage Drosophila melanogaster
embryos reversibly arrest upon hypoxia. We examined this rapid arrest in real time using a
fusion of green fluorescent protein and histone 2A. In addition to an interphase arrest,
mitosis was specifically blocked in metaphase, much like a checkpoint arrest. Nitric oxide,
recently proposed as a hypoxia signal inDrosophila, induced a reversible arrest of the …
or cell death (1). The nuclear division cycles of syncytial stage Drosophila melanogaster
embryos reversibly arrest upon hypoxia. We examined this rapid arrest in real time using a
fusion of green fluorescent protein and histone 2A. In addition to an interphase arrest,
mitosis was specifically blocked in metaphase, much like a checkpoint arrest. Nitric oxide,
recently proposed as a hypoxia signal inDrosophila, induced a reversible arrest of the …