Role of CCAA Nucleotide Repeats in Regulation of Hemoglobin and Hemoglobin-Haptoglobin Binding Protein Genes ofHaemophilus influenzae
Z Ren, H Jin, PW Whitby, DJ Morton… - Journal of …, 1999 - Am Soc Microbiol
Z Ren, H Jin, PW Whitby, DJ Morton, TL Stull
Journal of bacteriology, 1999•Am Soc MicrobiolHaemophilus influenzae utilizes hemoglobin and hemoglobin-haptoglobin as heme
sources. The H. influenzae hemoglobin-and hemoglobin-haptoglobin binding protein genes,
hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. Using an hgpA-lacZ
translational gene fusion, we demonstrate phase-variable expression of lacZ associated
with alteration in the length of the CCAA repeat region.
sources. The H. influenzae hemoglobin-and hemoglobin-haptoglobin binding protein genes,
hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. Using an hgpA-lacZ
translational gene fusion, we demonstrate phase-variable expression of lacZ associated
with alteration in the length of the CCAA repeat region.
Abstract
Haemophilus influenzae utilizes hemoglobin and hemoglobin-haptoglobin as heme sources. The H. influenzaehemoglobin- and hemoglobin-haptoglobin binding protein genes,hgpA, hgpB, and hgpC, contain lengths of tetrameric CCAA repeats. Using an hgpA-lacZtranslational gene fusion, we demonstrate phase-variable expression oflacZ associated with alteration in the length of the CCAA repeat region.
American Society for Microbiology