CD95 expression and CD95-mediated apoptosis of T cells in multiple sclerosis: No differences from normal individuals and no relation to HLA-DR2
F Zipp, E Faber, N Sommer, C Müller… - Journal of …, 1998 - Elsevier
CD95-mediated apoptosis is a potent endogenous pathway of T cell elimination that has
been suggested to be altered in multiple sclerosis (MS). MS is associated with the HLA-DR2,
Dw2, DQ6 HLA class II haplotype. We have previously reported that T cell lines from HLA-
DR2-positive individuals show enhanced production of tumor necrosis factor (TNF), a
cytokine homologous to CD95 ligand, in response to specific antigen. Here we have studied
CD95 expression and susceptibility to CD95-mediated apoptosis in peripheral blood …
been suggested to be altered in multiple sclerosis (MS). MS is associated with the HLA-DR2,
Dw2, DQ6 HLA class II haplotype. We have previously reported that T cell lines from HLA-
DR2-positive individuals show enhanced production of tumor necrosis factor (TNF), a
cytokine homologous to CD95 ligand, in response to specific antigen. Here we have studied
CD95 expression and susceptibility to CD95-mediated apoptosis in peripheral blood …