Thrombin receptor-mediated synovial proliferation in patients with rheumatoid arthritis
H Shin, T Nakajima, I Kitajima, K Shigeta… - Clinical immunology and …, 1995 - Elsevier
Synovial cell proliferation is one of the pathological bases of rheumatoid arthritis (RA).
Several cytokines including IL-1 and IL-6 and growth factors have been shown to be
involved in the synovial cell proliferation in RA. Thrombin is a multifunctional protease and
acts as a mitogen for several cell types through its specific receptor. To assess whether
thrombin is involved in overproliferation of rheumatoid synovial cells, we measured the
concentration of thrombin-antithrombin III (ATIII) complex (TAT) in synovial fluid obtained …
Several cytokines including IL-1 and IL-6 and growth factors have been shown to be
involved in the synovial cell proliferation in RA. Thrombin is a multifunctional protease and
acts as a mitogen for several cell types through its specific receptor. To assess whether
thrombin is involved in overproliferation of rheumatoid synovial cells, we measured the
concentration of thrombin-antithrombin III (ATIII) complex (TAT) in synovial fluid obtained …