[HTML][HTML] Calmodulin, a Junction between Two Independent Immunosuppressive Pathways in Jurkat T Cells (∗)
C Aussel, JP Breittmayer, C Pelassy… - Journal of Biological …, 1995 - ASBMB
Calmodulin (CaM) antagonists chlorpromazine, trifluoperazine, and N-(6-aminohexyl)-5-
chloro-1-naphthalene-sulfonamide HCl inhibit Jurkat T cell activation, as monitored by
measuring interleukin-2 synthesis in cells treated by a combination of CD3 monoclonal
antibody and phorbol myristate acetate. T cell activation with CD3 monoclonal antibody is
accompanied by a decreased synthesis of phosphatidylserine due to the release of Ca 2+
from the endoplasmic reticulum. CaM antagonists reverse the phosphatidylserine (PtdSer) …
chloro-1-naphthalene-sulfonamide HCl inhibit Jurkat T cell activation, as monitored by
measuring interleukin-2 synthesis in cells treated by a combination of CD3 monoclonal
antibody and phorbol myristate acetate. T cell activation with CD3 monoclonal antibody is
accompanied by a decreased synthesis of phosphatidylserine due to the release of Ca 2+
from the endoplasmic reticulum. CaM antagonists reverse the phosphatidylserine (PtdSer) …