Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy
D Wotton, JA Higgins, RE O'Hehir, JR Lamb… - Human immunology, 1995 - Elsevier
Stimulation of human CD4+ T-cell clones through the T-cell receptor (TcR) by high doses of
specific peptide results in the induction of a long-lived state of nonresponsiveness that has
been called anergy. During the induction of anergy, T cells are phenotypically similar to cells
responding to an immunogenic stimulus. The amount of TcR at the cell surface is
downmodulated, whereas the CD2 and CD25 receptors are increased. When restimulated,
however, anergic T cells fail to upregulate transcription of the IL-2 gene and in consequence …
specific peptide results in the induction of a long-lived state of nonresponsiveness that has
been called anergy. During the induction of anergy, T cells are phenotypically similar to cells
responding to an immunogenic stimulus. The amount of TcR at the cell surface is
downmodulated, whereas the CD2 and CD25 receptors are increased. When restimulated,
however, anergic T cells fail to upregulate transcription of the IL-2 gene and in consequence …