[HTML][HTML] Influence of HLA alleles on the rate of progression of vertically transmitted HIV infection in children: association of several HLA-DR13 alleles with long-term …
The influence of host immunogenetics on the outcome of vertically transmitted HIV infection
in children was examined in a multicenter cross sectional study of long term survivors and
rapid progressors. Sequence-based typing was performed for the DRB1, DQB1 and HLA-A
loci. 36.7% of 30 children surviving more than 8 years had one or more of the HLA-DR13
alleles, versus none of 14 rapidly progressing children who died within 2 years of age, p=
0.009, Haldane RR= 17.1. The alleles variably associated with this beneficial response to …
in children was examined in a multicenter cross sectional study of long term survivors and
rapid progressors. Sequence-based typing was performed for the DRB1, DQB1 and HLA-A
loci. 36.7% of 30 children surviving more than 8 years had one or more of the HLA-DR13
alleles, versus none of 14 rapidly progressing children who died within 2 years of age, p=
0.009, Haldane RR= 17.1. The alleles variably associated with this beneficial response to …