Detection of T helper responses, but not of human papillomavirus-specific cytotoxic T lymphocyte responses, after peptide vaccination of patients with cervical …
ME Ressing, WJ Van Driel, RMP Brandt… - Journal of …, 2000 - journals.lww.com
Abstract Human papillomavirus type 16 (HPV16)-encoded E7 oncoprotein is constitutively
expressed in cervical carcinoma cells and is required for cellular transformation to be
maintained. The E7 protein, therefore, forms an attractive target for T-cell–mediated immune
intervention to prevent or treat HPV16+ tumors. The authors performed a peptide-based
phase I/II vaccination trial to induce anti-tumor immune responses in patients with recurrent
or residual cervical carcinoma. Fifteen HLA-A* 0201+ patients with HPV16+ cervical …
expressed in cervical carcinoma cells and is required for cellular transformation to be
maintained. The E7 protein, therefore, forms an attractive target for T-cell–mediated immune
intervention to prevent or treat HPV16+ tumors. The authors performed a peptide-based
phase I/II vaccination trial to induce anti-tumor immune responses in patients with recurrent
or residual cervical carcinoma. Fifteen HLA-A* 0201+ patients with HPV16+ cervical …