Orphan neuropeptide NocII, a putative pronociceptin maturation product, stimulates locomotion in mice
S Florin, C Suaudeau, JC Meunier, J Costentin - Neuroreport, 1997 - journals.lww.com
NOCII is a heptadecapeptide whose sequence lies immediately downstream of nociceptin,
the newly discovered natural agonist of the ORL1 receptor, in pronociceptin, nociceptin's
precursor polypeptide. Since the sequence of NocII is framed by putative convertase
excision sites and it totally conserved across murine and human species, we have sought to
determine whether this orphan neuropeptide might by physiologically significant, ie
endowed with central biological activity in vivo. Intracerebroventricular administration of 10 …
the newly discovered natural agonist of the ORL1 receptor, in pronociceptin, nociceptin's
precursor polypeptide. Since the sequence of NocII is framed by putative convertase
excision sites and it totally conserved across murine and human species, we have sought to
determine whether this orphan neuropeptide might by physiologically significant, ie
endowed with central biological activity in vivo. Intracerebroventricular administration of 10 …