Antiviral agents in hepatitis B virus transfected cell lines: inhibitory and cytotoxic effect related to time of treatment
J Kruining, RA Heijtink, SW Schalm - Journal of hepatology, 1995 - Elsevier
The antiviral and cytotoxic effects of ara-arabinoside monophosphate, 2′, 3′, dideoxy-
cytidine, ganciclovir, 9-2 (-phosphonylmethoxyethyl) adenine, 2′, 3′-dideoxy-3′-
thiacytidine and recombinant interferon-alpha were studied using two human hepatitis B
virus transfected hepatoma cell lines, HepG2 2.2. 15 and HB 611. After 9 days of exposure,
starting on day 3 after seeding, inhibition of extracellular HBV-DNA expressed as ID50 was
in the 0.1–1.0 μM range for 2′, 3′-dideoxy-3′-thiacytidine and 9-2 …
cytidine, ganciclovir, 9-2 (-phosphonylmethoxyethyl) adenine, 2′, 3′-dideoxy-3′-
thiacytidine and recombinant interferon-alpha were studied using two human hepatitis B
virus transfected hepatoma cell lines, HepG2 2.2. 15 and HB 611. After 9 days of exposure,
starting on day 3 after seeding, inhibition of extracellular HBV-DNA expressed as ID50 was
in the 0.1–1.0 μM range for 2′, 3′-dideoxy-3′-thiacytidine and 9-2 …