Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy
CT Yeh, RN Chien, CM Chu, YF Liaw - Hepatology, 2000 - journals.lww.com
Abstract Tyrosine-methionine-aspartate-aspartate (YMDD)-motif mutants may emerge and
elicit immune clearance during prolonged lamivudine treatment. The aim of this study was to
investigate the virological events following development of the original mutants. Twenty-
three patients who developed YMDD-motif mutants during the Asian lamivudine trial were
included. Serial serum samples from these patients were subjected to sequence analysis to
identify new mutants. Site-directed mutagenesis experiments were performed to investigate …
elicit immune clearance during prolonged lamivudine treatment. The aim of this study was to
investigate the virological events following development of the original mutants. Twenty-
three patients who developed YMDD-motif mutants during the Asian lamivudine trial were
included. Serial serum samples from these patients were subjected to sequence analysis to
identify new mutants. Site-directed mutagenesis experiments were performed to investigate …