[HTML][HTML] Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-α-induced apoptosis by inducing heat shock protein 70 expression
YM Kim, ME De Vera, SC Watkins, TR Billiar - Journal of Biological …, 1997 - ASBMB
Nitric oxide (NO) and tumor necrosis factor-α (TNFα) play important roles in the
pathogenesis of liver disease during acute inflammation. The present study was designed to
elucidate the effect of NO pre-exposure on TNFα-induced hepatotoxicity. Pretreatment of
primary cultures of rat hepatocytes with the NO donor S-nitroso-N-acetylpenicillamine
(SNAP) induced the expression of heat shock protein 70 (HSP70) mRNA and protein, which
was associated with thermotolerance and cytoprotection from TNFα+ actinomycin D-induced …
pathogenesis of liver disease during acute inflammation. The present study was designed to
elucidate the effect of NO pre-exposure on TNFα-induced hepatotoxicity. Pretreatment of
primary cultures of rat hepatocytes with the NO donor S-nitroso-N-acetylpenicillamine
(SNAP) induced the expression of heat shock protein 70 (HSP70) mRNA and protein, which
was associated with thermotolerance and cytoprotection from TNFα+ actinomycin D-induced …