Speed congenics: a classic technique in the fast lane (relatively speaking)
E Wakeland, L Morel, K Achey, M Yui, J Longmate - Immunology today, 1997 - cell.com
E Wakeland, L Morel, K Achey, M Yui, J Longmate
Immunology today, 1997•cell.comMarker-assisted selection protocol (MASP)-based strategies produce congenic strains with
the target gene contained on clearly defined donor-derived genomic intervals in less than
half the number of generations required by the classic protocol, Thus, the quality and speed
of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland
and colleagues compare various MASP-based strategies and discuss their advantages with
reference to immunological traits.
the target gene contained on clearly defined donor-derived genomic intervals in less than
half the number of generations required by the classic protocol, Thus, the quality and speed
of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland
and colleagues compare various MASP-based strategies and discuss their advantages with
reference to immunological traits.
Abstract
Marker-assisted selection protocol (MASP)-based strategies produce congenic strains with the target gene contained on clearly defined donor-derived genomic intervals in less than half the number of generations required by the classic protocol, Thus, the quality and speed of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and discuss their advantages with reference to immunological traits.
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