[HTML][HTML] X-linked agammaglobulinemia and immunoglobulin deficiency with normal or elevated IgM: immunodeficiencies of B cell development and differentiation
R Fuleihan, N Ramesh, RS Geha - Advances in Immunology, 1995 - Elsevier
Publisher Summary X-linked immunoglobulin deficiency (XLA) and hyper immunoglobulin M
(HIGMX-1) are two immunodeficiency diseases resulting from defects in B cell development
and differentiation. XLA undoubtedly plays an important role in B cell development. In
contrast to patients with XLA, patients with HIGMX-1 have circulating B cells that synthesize
immunoglobulin M (IgM) and immunoglobulin D but fail to switch to the production of other
immunoglobulin isotypes. HIGMX-1 patients also differ from XLA patients in their capacity to …
(HIGMX-1) are two immunodeficiency diseases resulting from defects in B cell development
and differentiation. XLA undoubtedly plays an important role in B cell development. In
contrast to patients with XLA, patients with HIGMX-1 have circulating B cells that synthesize
immunoglobulin M (IgM) and immunoglobulin D but fail to switch to the production of other
immunoglobulin isotypes. HIGMX-1 patients also differ from XLA patients in their capacity to …