[HTML][HTML] Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
M Muramatsu, VS Sankaranand, S Anant… - Journal of Biological …, 1999 - ASBMB
We have identified a novel gene referred to asactivation-induced deaminase (AID) by
subtraction of cDNAs derived from switch-induced and uninduced murine B lymphoma
CH12F3-2 cells, more than 80% of which switch exclusively to IgA upon stimulation. The
amino acid sequence encoded by AID cDNA is homologous to that of apolipoprotein B
(apoB) mRNA-editing enzyme, catalytic polypeptide 1 (APOBEC-1), a type of cytidine
deaminase that constitutes a catalytic subunit for the apoB mRNA-editing complex. In vitro …
subtraction of cDNAs derived from switch-induced and uninduced murine B lymphoma
CH12F3-2 cells, more than 80% of which switch exclusively to IgA upon stimulation. The
amino acid sequence encoded by AID cDNA is homologous to that of apolipoprotein B
(apoB) mRNA-editing enzyme, catalytic polypeptide 1 (APOBEC-1), a type of cytidine
deaminase that constitutes a catalytic subunit for the apoB mRNA-editing complex. In vitro …