[HTML][HTML] Dynamin: a molecular motor with pinchase action
MA McNiven - Cell, 1998 - cell.com
MA McNiven
Cell, 1998•cell.com), has recently been implicated in the liberation of endocytic vesicles from the plasma
membrane. A culmination of studies using either the temperature-sensitive mutant fruit fly
shibirets, which possesses a point mutation near the GTP-binding domain of dynamin, or
overexpression of mutant dynamin in mammalian cells is consistent with the concept that
dynamin participates in clathrin-based endocytic processes. From these observations we
had originally proposed that dynamin may act as a “molecular pinchase”(
membrane. A culmination of studies using either the temperature-sensitive mutant fruit fly
shibirets, which possesses a point mutation near the GTP-binding domain of dynamin, or
overexpression of mutant dynamin in mammalian cells is consistent with the concept that
dynamin participates in clathrin-based endocytic processes. From these observations we
had originally proposed that dynamin may act as a “molecular pinchase”(
), has recently been implicated in the liberation of endocytic vesicles from the plasma membrane. A culmination of studies using either the temperature-sensitive mutant fruit fly shibirets, which possesses a point mutation near the GTP-binding domain of dynamin, or overexpression of mutant dynamin in mammalian cells is consistent with the concept that dynamin participates in clathrin-based endocytic processes. From these observations we had originally proposed that dynamin may act as a “molecular pinchase”(
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