JAK/STAT signaling by cytokine receptors
KD Liu, SL Gaffen, MA Goldsmith - Current opinion in immunology, 1998 - Elsevier
KD Liu, SL Gaffen, MA Goldsmith
Current opinion in immunology, 1998•ElsevierThe JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine
receptors transduce intracellular signals. This system is regulated at multiple levels,
including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops.
Gene deletion studies have implicated selected STAT factors as pedominant mediators for a
limited number of lymphokines. This signaling pathway influences normal cell survival and
growth mechanisms and may contribute to oncogenic transformation.
receptors transduce intracellular signals. This system is regulated at multiple levels,
including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops.
Gene deletion studies have implicated selected STAT factors as pedominant mediators for a
limited number of lymphokines. This signaling pathway influences normal cell survival and
growth mechanisms and may contribute to oncogenic transformation.
The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicated selected STAT factors as pedominant mediators for a limited number of lymphokines. This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation.
Elsevier