[HTML][HTML] Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
RA Seder, R Ahmed - Nature immunology, 2003 - nature.com
RA Seder, R Ahmed
Nature immunology, 2003•nature.comAbstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent
evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell
differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make
the transition to effector and/or memory cells and discusses the implications of these findings
for vaccine development.
activation, resulting in the generation of effector and long-lived memory T cells. Recent
evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell
differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make
the transition to effector and/or memory cells and discusses the implications of these findings
for vaccine development.
Abstract
Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development.
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