[HTML][HTML] Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor α-mediated …

RAK Srivastava, N Srivastava, M Averna, RC Lin… - Journal of Biological …, 1997 - ASBMB
The antiatherogenic property of estrogens is mediated via at least two mechanisms: first by
affecting plasma lipoprotein profiles, and second by affecting the components of the vessel
wall. Raising plasma apolipoprotein E (apoE) in mice protects them against diet-induced
atherosclerosis (Shimano, H., Yamada, N., Katsuki, M., Gotoda, T., Harada, K., Murase, T.,
Fukuzawa, C., Takaku, F., and Yazaka, Y.(1992) Proc. Natl. Acad. Sci. USA 89, 1750–1754).
It is possible that estrogen may be antiatherogenic at least in part by increasing plasma …