Inhibition of cholesterylester accumulation by 17β-estradiol in macrophages through activation of neutral cholesterol esterase
T Tomita, F Sawamura, R Uetsuka, T Chiba… - … et Biophysica Acta (BBA …, 1996 - Elsevier
Premenopausal women are at a lower risk of coronary heart diseases relative to age
matched men. However, the underlying mechanisms are not clearly understood. This article
studies the effects of 17β-estradiol (17β-E2) at physiological concentrations on the
cholesterylester metabolism in macrophages (J774 A. 1 cells) with a particular focus on
neutral cholesterol esterase (N-CEase). Cells were incubated with β-VLDL,[1-14C] oleic
acid and 17β-E2 (0.25 and 2.5 nM). 17β-E2 dose-dependently reduced cholesteryl-[1-14C] …
matched men. However, the underlying mechanisms are not clearly understood. This article
studies the effects of 17β-estradiol (17β-E2) at physiological concentrations on the
cholesterylester metabolism in macrophages (J774 A. 1 cells) with a particular focus on
neutral cholesterol esterase (N-CEase). Cells were incubated with β-VLDL,[1-14C] oleic
acid and 17β-E2 (0.25 and 2.5 nM). 17β-E2 dose-dependently reduced cholesteryl-[1-14C] …