Effects of estradiol on platelet aggregation in mouse mesenteric arterioles and ex vivo
WI Rosenblum, F El-Sabban, AD Allen, GH Nelson… - Thrombosis research, 1985 - Elsevier
Mice were implanted subcutaneously with a pellet containing 0.5 mg estradiol or with a
placebo. Eight to 12 days later platelet aggregation was produced in mesenteric arterioles
by injuring their endothelium in vivo with a noxious light/dye stimulus. The time between the
onset of the noxious stimulus and the appearance of platelet aggregates was significantly
shortened (p<. 01) in the estradiol treated mice. In contrast to this enhancement of
aggregation, when platelets were tested ex vivo in platelet rich plasma (PRP), aggregation …
placebo. Eight to 12 days later platelet aggregation was produced in mesenteric arterioles
by injuring their endothelium in vivo with a noxious light/dye stimulus. The time between the
onset of the noxious stimulus and the appearance of platelet aggregates was significantly
shortened (p<. 01) in the estradiol treated mice. In contrast to this enhancement of
aggregation, when platelets were tested ex vivo in platelet rich plasma (PRP), aggregation …