Immunolocalization of the four prostaglandin E2 receptor proteins EP1, EP2, EP3, and EP4 in human kidney
R Morath, T Klein, HW SEYBERTH… - Journal of the American …, 1999 - journals.lww.com
Four prostaglandin E 2 receptor subtypes designated EP1, EP2, EP3, and EP4 have been
shown to mediate a variety of effects of prostaglandin E 2 (PGE 2) on glomerular
hemodynamics, tubular salt and water reabsorption, and on blood vessels in the human
kidney. Despite the important role of renal PGE 2, the localization of PGE 2 receptor proteins
in the human kidney is unknown. The present study used antipeptide antibodies to the EP1
to EP4 receptor proteins for immunolocalization in human kidney tissue. Immunoblot studies …
shown to mediate a variety of effects of prostaglandin E 2 (PGE 2) on glomerular
hemodynamics, tubular salt and water reabsorption, and on blood vessels in the human
kidney. Despite the important role of renal PGE 2, the localization of PGE 2 receptor proteins
in the human kidney is unknown. The present study used antipeptide antibodies to the EP1
to EP4 receptor proteins for immunolocalization in human kidney tissue. Immunoblot studies …