Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats
M Hosoi, T Oka, M Abe, T Hori, H Yamamoto, K Mine… - Pain, 1999 - Elsevier
The effects of microinjection of prostaglandin E2 (PGE2)(50 fg–50 ng/0.2 μl) into the
ventromedial hypothalamus (VMH) on nociception were studied using a hot-plate test in rats.
Microinjection of PGE2 (5–500 pg and 50 ng/0.2 μl) into the VMH significantly prolonged the
paw-withdrawal latency on a hot plate 5 and 10 min after injection, respectively. Maximal
prolongation was obtained 5 min after the injection of PGE2 at 5 pg. Subsequently, to
determine whether the PGE2 receptor subtype EP1 is involved in the PGE2-induced …
ventromedial hypothalamus (VMH) on nociception were studied using a hot-plate test in rats.
Microinjection of PGE2 (5–500 pg and 50 ng/0.2 μl) into the VMH significantly prolonged the
paw-withdrawal latency on a hot plate 5 and 10 min after injection, respectively. Maximal
prolongation was obtained 5 min after the injection of PGE2 at 5 pg. Subsequently, to
determine whether the PGE2 receptor subtype EP1 is involved in the PGE2-induced …