Homocysteine and atherothrombosis

GN Welch, J Loscalzo - New England journal of medicine, 1998 - Mass Medical Soc
GN Welch, J Loscalzo
New England journal of medicine, 1998Mass Medical Soc
In 1969, McCully made the clinical observation linking elevated plasma homocyst (e) ine
concentrations with vascular disease. 1 He reported autopsy evidence of extensive arterial
thrombosis and atherosclerosis in two children with elevated plasma homocyst (e) ine
concentrations and homocystinuria. On the basis of this observation, he proposed that
elevated plasma homocyst (e) ine (hyperhomocyst (e) inemia) can cause atherosclerotic
vascular disease. The term “homocyst (e) ine” is used to define the combined pool of …
In 1969, McCully made the clinical observation linking elevated plasma homocyst(e)ine concentrations with vascular disease.1 He reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocyst(e)ine concentrations and homocystinuria. On the basis of this observation, he proposed that elevated plasma homocyst(e)ine (hyperhomocyst(e)inemia) can cause atherosclerotic vascular disease. The term “homocyst(e)ine” is used to define the combined pool of homocysteine, homocystine, mixed disulfides involving homocysteine, and homocysteine thiolactone found in the plasma of patients with hyperhomocyst(e)inemia.
Subsequent investigations have confirmed McCully's hypothesis, and it has recently become clear that hyperhomocyst(e)inemia is an independent risk factor . . .
The New England Journal Of Medicine