[HTML][HTML] The lipid peroxidation product 4-hydroxy-2, 3-nonenal inhibits constitutive and inducible activity of nuclear factor κB in neurons
Peroxidation of membrane lipids occurs in many different neurodegenerative conditions
including stroke, and Alzheimer's and Parkinson's diseases. Recent findings suggest that
lipid peroxidation can promote neuronal death by a mechanism involving production of the
toxic aldehyde 4-hydroxy-2, 3-nonenal (HNE), which may act by covalently modifying
proteins and impairing their function. The transcription factor NF-κB can prevent neuronal
death in experimental models of neurodegenerative disorders by inducing the expression of …
including stroke, and Alzheimer's and Parkinson's diseases. Recent findings suggest that
lipid peroxidation can promote neuronal death by a mechanism involving production of the
toxic aldehyde 4-hydroxy-2, 3-nonenal (HNE), which may act by covalently modifying
proteins and impairing their function. The transcription factor NF-κB can prevent neuronal
death in experimental models of neurodegenerative disorders by inducing the expression of …