[HTML][HTML] Secreted β-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-κB and stabilization of calcium …
Q Guo, N Robinson, MP Mattson - Journal of Biological Chemistry, 1998 - ASBMB
Mutations in the presenilin-1 (PS-1) gene account for approximately 50% of the cases of
autosomal dominant, early onset, inherited forms of Alzheimer's disease (AD). PS-1 is an
integral membrane protein expressed in neurons and is localized primarily in the
endoplasmic reticulum (ER). PS-1 mutations may promote neuronal degeneration by
altering the processing of the β-amyloid precursor protein (APP) and/or by engaging
apoptotic pathways. Alternative processing of APP in AD may increase production of …
autosomal dominant, early onset, inherited forms of Alzheimer's disease (AD). PS-1 is an
integral membrane protein expressed in neurons and is localized primarily in the
endoplasmic reticulum (ER). PS-1 mutations may promote neuronal degeneration by
altering the processing of the β-amyloid precursor protein (APP) and/or by engaging
apoptotic pathways. Alternative processing of APP in AD may increase production of …