[HTML][HTML] Oncogenic Ras enhances NF-κB transcriptional activity through Raf-dependent and Raf-independent mitogen-activated protein kinase signaling pathways
JL Norris, AS Baldwin - Journal of Biological Chemistry, 1999 - ASBMB
Tumors frequently contain mutations inras genes, resulting in constitutive activation of Ras-
activated signaling pathways. The ultimate targets of these signal transduction cascades are
transcription factors required for cellular proliferation. Understanding how constitutive
activation of Ras contributes to tumorigenesis requires an understanding of both the
signaling pathways that Ras activates and how these pathways in turn regulate gene
expression. Gene expression from κB sites is enhanced in cells transformed with activated …
activated signaling pathways. The ultimate targets of these signal transduction cascades are
transcription factors required for cellular proliferation. Understanding how constitutive
activation of Ras contributes to tumorigenesis requires an understanding of both the
signaling pathways that Ras activates and how these pathways in turn regulate gene
expression. Gene expression from κB sites is enhanced in cells transformed with activated …