[HTML][HTML] Plasma lipoproteins promote the release of bacterial lipopolysaccharide from the monocyte cell surface
RL Kitchens, G Wolfbauer, JJ Albers… - Journal of Biological …, 1999 - ASBMB
When bacterial lipopolysaccharide (LPS) enters the bloodstream, it is thought to have two
general fates. If LPS binds to circulating leukocytes, it triggers innate host defense
mechanisms and often elicits toxic reactions. If instead LPS binds to plasma lipoproteins, its
bioactivity is largely neutralized. This study shows that lipoproteins can also take up LPS that
has first bound to leukocytes. When monocytes were loaded with [3 H] LPS and then
incubated in plasma, they released over 70% of the cell-associated [3 H] LPS into …
general fates. If LPS binds to circulating leukocytes, it triggers innate host defense
mechanisms and often elicits toxic reactions. If instead LPS binds to plasma lipoproteins, its
bioactivity is largely neutralized. This study shows that lipoproteins can also take up LPS that
has first bound to leukocytes. When monocytes were loaded with [3 H] LPS and then
incubated in plasma, they released over 70% of the cell-associated [3 H] LPS into …