[HTML][HTML] Nuclear IκBβ maintains persistent NF-κB activation in HIV-1-infected myeloid cells
C DeLuca, L Petropoulos, D Zmeureanu… - Journal of Biological …, 1999 - ASBMB
Monocytic cells exhibit constitutive NF-κB activation upon infection with human
immunodeficiency virus-1 (HIV-1). Because IκBβ has been implicated in maintaining NF-κB·
DNA binding, we sought to investigate whether IκBβ was involved in maintaining persistent
NF-κB activation in HIV-1-infected monocytic cell lines. IκBβ was present in the nucleus of
HIV-1-infected cells and participated in the ternary complex formation with NF-κB and DNA.
In contrast to uninfected cells, the addition of recombinant glutathione S-transferase-IκBα …
immunodeficiency virus-1 (HIV-1). Because IκBβ has been implicated in maintaining NF-κB·
DNA binding, we sought to investigate whether IκBβ was involved in maintaining persistent
NF-κB activation in HIV-1-infected monocytic cell lines. IκBβ was present in the nucleus of
HIV-1-infected cells and participated in the ternary complex formation with NF-κB and DNA.
In contrast to uninfected cells, the addition of recombinant glutathione S-transferase-IκBα …