Towards a better aspirin.
J Vane - Nature, 1994 - search.ebscohost.com
J Vane
Nature, 1994•search.ebscohost.comDiscusses the implications of the crystal structure of the membrane protein prostaglandin H
(2) synthase-1 on finding better aspirin-like drugs. Actions of the two known isoforms of
cyclooxygenase; Oxidation of arachidonic acid to prostaglandin G (2); Cyclooxygenase
active site; Consequences of the activation of the constitutive enzyme; Search for better non-
steroid anti-inflammatory drugs.
(2) synthase-1 on finding better aspirin-like drugs. Actions of the two known isoforms of
cyclooxygenase; Oxidation of arachidonic acid to prostaglandin G (2); Cyclooxygenase
active site; Consequences of the activation of the constitutive enzyme; Search for better non-
steroid anti-inflammatory drugs.
Abstract
Discusses the implications of the crystal structure of the membrane protein prostaglandin H (2) synthase-1 on finding better aspirin-like drugs. Actions of the two known isoforms of cyclooxygenase; Oxidation of arachidonic acid to prostaglandin G (2); Cyclooxygenase active site; Consequences of the activation of the constitutive enzyme; Search for better non-steroid anti-inflammatory drugs.
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