The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation
S Gerondakis, R Grumont, I Rourke… - Current opinion in …, 1998 - Elsevier
S Gerondakis, R Grumont, I Rourke, M Grossmann
Current opinion in immunology, 1998•ElsevierThe activation of B and T cells by a wide range of stimuli can rapidly induce specific gene
expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear
factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent
findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of
cell division, apoptosis and differentiation that accompany lymphocyte activation.
expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear
factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent
findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of
cell division, apoptosis and differentiation that accompany lymphocyte activation.
The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-κB (NF-κB) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-κB family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.
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