[HTML][HTML] Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-β1 on programmed cell death …
R Rajah, B Valentinis, P Cohen - Journal of Biological Chemistry, 1997 - ASBMB
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is known to block IGF action and
inhibit cell growth. IGFBP-3 is thought to act by sequestering free IGFs or, possibly, act via a
novel IGF-independent mechanism. Supporting its role as a primary growth inhibitor, IGFBP-
3 production has been shown to be increased by cell growth-inhibitory agents, such as
transforming growth factor-β (TGF-β), and the tumor suppressor gene p53. In this paper, we
demonstrate, for the first time, a novel function of IGFBP-3 as an apoptosis-inducing agent …
inhibit cell growth. IGFBP-3 is thought to act by sequestering free IGFs or, possibly, act via a
novel IGF-independent mechanism. Supporting its role as a primary growth inhibitor, IGFBP-
3 production has been shown to be increased by cell growth-inhibitory agents, such as
transforming growth factor-β (TGF-β), and the tumor suppressor gene p53. In this paper, we
demonstrate, for the first time, a novel function of IGFBP-3 as an apoptosis-inducing agent …