Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition
Y Oh, HL Müller, G Lamson, RG Rosenfeld - Journal of Biological Chemistry, 1993 - ASBMB
Estrogen receptor-negative Hs578T human breast cancer cells secrete insulin-like growth
factor binding protein (IGFBP)-3 and IGFBP-4 as major binding protein (BP) species. Our
previous immunohistochemical studies (Oh, Y., Müller, HL, Pham, H., Lamson, G., and
Rosenfeld, RG (1992) Endocrinology 131, 3123-3125) have demonstrated the existence of
cell surface-associated IGFBP-3 and release of cell surface-associated IGFBP-3 into
conditioned media by addition of IGF peptide in Hs578T cells. In this study, we have …
factor binding protein (IGFBP)-3 and IGFBP-4 as major binding protein (BP) species. Our
previous immunohistochemical studies (Oh, Y., Müller, HL, Pham, H., Lamson, G., and
Rosenfeld, RG (1992) Endocrinology 131, 3123-3125) have demonstrated the existence of
cell surface-associated IGFBP-3 and release of cell surface-associated IGFBP-3 into
conditioned media by addition of IGF peptide in Hs578T cells. In this study, we have …