Increased nuclear factor-kappaB activation in colitis of interleukin-2-deficient mice
F Yang, WJS De Villiers, EY Lee, CJ McClain… - Journal of Laboratory …, 1999 - Elsevier
Recent studies support nuclear factor-kappaB (NF-κB) as a critical transcription factor in
inflammatory bowel disease. We examined NF-κB and its inhibitors, IκB-α and IκB-β, in the
colitis of interleukin-2 deficient (IL-2−/−) mice at the ages of 5, 10, and 15 weeks and
compared them with those of age-matched wild-type mice. Colon levels of nuclear NF-κB
and mRNA for NF-κB responsive cytokines interleukin-1β and tumor necrosis factor-alpha
were markedly increased in interleukin-2−/− mice. Colon interleukin-1β protein levels were …
inflammatory bowel disease. We examined NF-κB and its inhibitors, IκB-α and IκB-β, in the
colitis of interleukin-2 deficient (IL-2−/−) mice at the ages of 5, 10, and 15 weeks and
compared them with those of age-matched wild-type mice. Colon levels of nuclear NF-κB
and mRNA for NF-κB responsive cytokines interleukin-1β and tumor necrosis factor-alpha
were markedly increased in interleukin-2−/− mice. Colon interleukin-1β protein levels were …