[HTML][HTML] Parathyroid hormone regulates the rat collagenase-3 promoter in osteoblastic cells through the cooperative interaction of the activator protein-1 site and the …

N Selvamurugan, WY Chou, AT Pearman… - Journal of Biological …, 1998 - ASBMB
Parathyroid hormone induces collagenase-3 gene transcription in rat osteoblastic cells.
Here, we characterized the basal, parathyroid hormone regulatory regions of the rat
collagenase-3 gene and the proteins involved in this regulation. The minimal parathyroid
hormone-responsive region was observed to be between base pairs− 38 and− 148. Deleted
and mutated constructs showed that the activator protein-1 and the runt domain binding sites
are both required for basal expression and parathyroid hormone activation of this gene. The …