[HTML][HTML] Stat1 depends on transcriptional synergy with Sp1 (∗)
DC Look, MR Pelletier, RM Tidwell, WT Roswit… - Journal of Biological …, 1995 - ASBMB
STAT (signal transducer and activator of transcription) proteins combine with cytokine
receptors and receptor-associated kinases in distinct protein/protein interactions that are
critical for STAT-dependent signal transduction events, but the nature of any subsequent
STAT interactions with DNA-binding proteins in the nucleus is less certain. Based on assays
of DNA/protein binding and activity of transfected reporter plasmids, we determined that
occupation of contiguous DNA-binding sites for Stat1 (the first member of the STAT family) …
receptors and receptor-associated kinases in distinct protein/protein interactions that are
critical for STAT-dependent signal transduction events, but the nature of any subsequent
STAT interactions with DNA-binding proteins in the nucleus is less certain. Based on assays
of DNA/protein binding and activity of transfected reporter plasmids, we determined that
occupation of contiguous DNA-binding sites for Stat1 (the first member of the STAT family) …