[HTML][HTML] Thyroid hormone-independent interaction between the thyroid hormone receptor β2 amino terminus and coactivators
C Oberste-Berghaus, K Zanger, K Hashimoto… - Journal of Biological …, 2000 - ASBMB
Thyroid hormone receptors (TRs) mediate hormone action by binding to DNA response
elements (TREs) and either activating or repressing gene expression in the presence of
ligand, T 3. Coactivator recruitment to the AF-2 region of TR in the presence of T 3 is central
to this process. The different TR isoforms, TR-β1, TR-β2, and TR-α1, share strong homology
in their DNA-and ligand-binding domains but differ in their amino-terminal domains.
Because TR-β2 exhibits greater T 3-independent activation on TREs than other TR isoforms …
elements (TREs) and either activating or repressing gene expression in the presence of
ligand, T 3. Coactivator recruitment to the AF-2 region of TR in the presence of T 3 is central
to this process. The different TR isoforms, TR-β1, TR-β2, and TR-α1, share strong homology
in their DNA-and ligand-binding domains but differ in their amino-terminal domains.
Because TR-β2 exhibits greater T 3-independent activation on TREs than other TR isoforms …