[HTML][HTML] Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein
T Monden, FE Wondisford, AN Hollenberg - Journal of Biological Chemistry, 1997 - ASBMB
The thyroid hormone receptor (TR) regulates the expression of target genes upon binding to
triiodothyronine (T 3) response elements. In the presence of T 3, the TR recruits coactivating
proteins that both modulate and integrate the ligand response. We report here the cloning of
a novel protein using the TR ligand-binding domain as bait in the yeast two-hybrid system.
Analysis of a putative full-length clone demonstrates a cDNA sequence that encodes a
protein of 920 amino acids with a size of 120 kDa (p120). Alignment with known sequences …
triiodothyronine (T 3) response elements. In the presence of T 3, the TR recruits coactivating
proteins that both modulate and integrate the ligand response. We report here the cloning of
a novel protein using the TR ligand-binding domain as bait in the yeast two-hybrid system.
Analysis of a putative full-length clone demonstrates a cDNA sequence that encodes a
protein of 920 amino acids with a size of 120 kDa (p120). Alignment with known sequences …