Turnover rate of skeletal alkaline phosphatase in humans.
S Posen, HS Grunstein - Clinical chemistry, 1982 - academic.oup.com
S Posen, HS Grunstein
Clinical chemistry, 1982•academic.oup.comTwo patients with Paget's disease of bone were subjected to plasmapheresis. Alkaline
phosphatase activities of serum declined sharply, but returned to preplasmapheresis values
within eight to 10 days. The biological half-life of circulating skeletal alkaline phosphatase,
as calculated from these experiments, is between 1.12 and 2.15 days.
phosphatase activities of serum declined sharply, but returned to preplasmapheresis values
within eight to 10 days. The biological half-life of circulating skeletal alkaline phosphatase,
as calculated from these experiments, is between 1.12 and 2.15 days.
Abstract
Two patients with Paget's disease of bone were subjected to plasmapheresis. Alkaline phosphatase activities of serum declined sharply, but returned to preplasmapheresis values within eight to 10 days. The biological half-life of circulating skeletal alkaline phosphatase, as calculated from these experiments, is between 1.12 and 2.15 days.
Oxford University Press