SEVERAL important developments have recently given new impetus to prevention of
coronary heart disease (CHD) through control of the plasma cholesterol level. Three
advances have been particularly dramatic. First, the Nobel prize in medicine was awarded in
1985 to Drs Joseph Goldstein and Michael Brown for their discovery of cell-surface
receptors for low-density lipoproteins (LDLs); their finding was fundamental to our
understanding of how plasma cholesterol levels are controlled. Second, the Lipid Research …