[HTML][HTML] Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Mediates the Cellular Internalization and Degradation of Thrombospondin: A …
I Mikhailenko, MZ Kounnas, DK Strickland - Journal of Biological Chemistry, 1995 - ASBMB
Thrombospondin (TSP) is a cell and matrix glycoprotein that interacts with a variety of
molecules. Newly synthesized thrombospondin is either incorporated into the extracellular
matrix, or binds to the cell surface where it is rapidly internalized and degraded (McKeown-
Longo, PJ, Hanning, R., and Mosher, DF (1984) J. Cell Biol. 98, 22-28). In the current
investigation we identify the low density lipoprotein receptor-related protein/α 2-
macroglobulin receptor (LRP) as a receptor responsible for mediating the internalization of …
molecules. Newly synthesized thrombospondin is either incorporated into the extracellular
matrix, or binds to the cell surface where it is rapidly internalized and degraded (McKeown-
Longo, PJ, Hanning, R., and Mosher, DF (1984) J. Cell Biol. 98, 22-28). In the current
investigation we identify the low density lipoprotein receptor-related protein/α 2-
macroglobulin receptor (LRP) as a receptor responsible for mediating the internalization of …