[HTML][HTML] Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt

A Craxton, A Jiang, T Kurosaki, EA Clark - Journal of Biological Chemistry, 1999 - ASBMB
Activation of Akt by multiple stimuli including B cell antigen receptor (BCR) engagement
requires phosphatidylinositol 3-kinase and regulates processes including cell survival,
proliferation, and metabolism. BCR cross-linking activates three families of non-receptor
protein tyrosine kinases (PTKs) and these are transducers of signaling events including
phospholipase C and mitogen-activated protein kinase activation; however, the relative
roles of PTKs in BCR-mediated Akt activation are unknown. We examined Akt activation in …