[HTML][HTML] Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration
HR Reiske, SC Kao, LA Cary, JL Guan, JF Lai… - Journal of Biological …, 1999 - ASBMB
We have previously shown that overexpression of focal adhesion kinase (FAK) in Chinese
hamster ovary (CHO) cells promoted their migration on fibronectin. This effect was
dependent on the phosphorylation of FAK at Tyr-397. This residue was known to serve as a
binding site for both Src and phosphatidylinositol 3-kinase (PI3K), implying that either one or
both are required for FAK to promote cell migration. In this study, we have examined the role
of PI3K in FAK-promoted cell migration. We have demonstrated that the PI3K inhibitors …
hamster ovary (CHO) cells promoted their migration on fibronectin. This effect was
dependent on the phosphorylation of FAK at Tyr-397. This residue was known to serve as a
binding site for both Src and phosphatidylinositol 3-kinase (PI3K), implying that either one or
both are required for FAK to promote cell migration. In this study, we have examined the role
of PI3K in FAK-promoted cell migration. We have demonstrated that the PI3K inhibitors …