Effects of enalapril on erythrocytosis after renal transplantation
RS Gaston, BA Julian, AG Diethelm… - Annals of internal …, 1991 - acpjournals.org
RS Gaston, BA Julian, AG Diethelm, JJ Curtis
Annals of internal medicine, 1991•acpjournals.orgExcerpt Erythrocytosis afflicts 4% to 17% of renal allograft recipients. It appears most often
within the first year after transplant, usually in patients with excellent graft function, and is
associated with an increased risk for thromboembolic events (1). Although the
pathophysiology is poorly defined, it may relate to excess production of erythropoietin by
native kidneys (2). The standard therapy is serial phlebotomy (1), but no treatment has
proved optimal. A recent report of enalapril-associated anemia in renal transplant recipients …
within the first year after transplant, usually in patients with excellent graft function, and is
associated with an increased risk for thromboembolic events (1). Although the
pathophysiology is poorly defined, it may relate to excess production of erythropoietin by
native kidneys (2). The standard therapy is serial phlebotomy (1), but no treatment has
proved optimal. A recent report of enalapril-associated anemia in renal transplant recipients …
Excerpt
Erythrocytosis afflicts 4% to 17% of renal allograft recipients. It appears most often within the first year after transplant, usually in patients with excellent graft function, and is associated with an increased risk for thromboembolic events (1). Although the pathophysiology is poorly defined, it may relate to excess production of erythropoietin by native kidneys (2). The standard therapy is serial phlebotomy (1), but no treatment has proved optimal. A recent report of enalapril-associated anemia in renal transplant recipients (3) led to a trial of this agent as therapy for post-transplant erythrocytosis.
Methods
Twelve renal allograft recipients (mean age, 39 ±...
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