IL-4, IgE, and interferon-γ production in pulmonary blastomycosis: comparison in mice untreated, immunized, or treated with an antifungal (SCH 39304)
E Brummer, LH Hanson, DA Stevens - Cellular immunology, 1993 - Elsevier
The purpose of this study was to determine if there is a correlation between production of
certain lymphokines in progressive blastomycosis in untreated mice, resistance to infection
in immunized mice, and cure in antifungal triazole (SCH 39304)-treated mice. Infection was
measured by colony-forming units of Blastomyces dermatitidis in lungs. Serum level of IgE
was used as a marker for in vivo IL-4 activity. Serum IgE levels rose in untreated mice from 6
μg/ml at 3 weeks to 24 μg/ml by the fourth week as their infection progressed. This …
certain lymphokines in progressive blastomycosis in untreated mice, resistance to infection
in immunized mice, and cure in antifungal triazole (SCH 39304)-treated mice. Infection was
measured by colony-forming units of Blastomyces dermatitidis in lungs. Serum level of IgE
was used as a marker for in vivo IL-4 activity. Serum IgE levels rose in untreated mice from 6
μg/ml at 3 weeks to 24 μg/ml by the fourth week as their infection progressed. This …