Proteolytic control of growth factor availability
DB Rifkin, R Mazzieri, JS Munger, I Noguera, J Sung - Apmis, 1999 - Wiley Online Library
DB Rifkin, R Mazzieri, JS Munger, I Noguera, J Sung
Apmis, 1999•Wiley Online LibraryMost growth factors are released from cells in a form that does not permit immediate
interaction with their high affinity receptors. An important mechanism for presentation of
these released latent growth factors is activation by the plasminogen activator‐plasmin
system. The involvement of this system in the biology of Transforming Growth Factor‐β (TGF‐
β) is reviewed.
interaction with their high affinity receptors. An important mechanism for presentation of
these released latent growth factors is activation by the plasminogen activator‐plasmin
system. The involvement of this system in the biology of Transforming Growth Factor‐β (TGF‐
β) is reviewed.
Most growth factors are released from cells in a form that does not permit immediate interaction with their high affinity receptors. An important mechanism for presentation of these released latent growth factors is activation by the plasminogen activator‐plasmin system. The involvement of this system in the biology of Transforming Growth Factor‐β (TGF‐β) is reviewed.
Wiley Online Library