Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
HA Chapman - Current opinion in cell biology, 1997 - Elsevier
HA Chapman
Current opinion in cell biology, 1997•ElsevierCellular migration is critically dependent on an interplay between forces of attachment and
detachment. Recent studies show that the serine protease urokinase and its major inhibitor
and receptor regulate the adhesive properties of integrins, at least in part through initiation of
cellular signals. These new functions for an old protease system imply intricate connections
between proteolysis and adhesion that operate at the cell surface to regulate migration.
detachment. Recent studies show that the serine protease urokinase and its major inhibitor
and receptor regulate the adhesive properties of integrins, at least in part through initiation of
cellular signals. These new functions for an old protease system imply intricate connections
between proteolysis and adhesion that operate at the cell surface to regulate migration.
Cellular migration is critically dependent on an interplay between forces of attachment and detachment. Recent studies show that the serine protease urokinase and its major inhibitor and receptor regulate the adhesive properties of integrins, at least in part through initiation of cellular signals. These new functions for an old protease system imply intricate connections between proteolysis and adhesion that operate at the cell surface to regulate migration.
Elsevier