We investigated the relationship between the pharmacokinetics of exogenous molecules
and transcapillary flux by studying the intravascular and tissue content and the histologic
distribution of Evans blue in guinea pigs. Pharmacokinetic analysis demonstrated that 87%
of the decline in intravascular Evans blue during the first 3 hours after administration was a
result of transvascular flux to tissue compartments. Rapidly and slowly equilibrating
compartments were identified. Greater than 90% of the clearances in lung and heart were …